摘要 |
<p>The present invention relates to process for the preparation of racemic and optically pure enantiomers of 1-cyclopropyl-6-fluoro-8-methyl-7-(4-amino-3,3-dimethyl-piperidin-1-yl)-4- oxo-l,4-dihydro-quinolin-3-carboxylic acid and salts thereof. The present invention also provides novel crystalline forms of racemic and optically pure enantiomers of 1-cyclopropyl- 6-fluoro-8-methyl-7-(4-amino-3,3-dimethyl-piperidin-1 -yl)-4-oxo-1,4-dihydro-quinolin-3- carboxylic acid hydrochloride and compositions containing polymorphs. The present invention further provides pure (RS)-(±)-4-amino-3,3-dimethyl-piperidine and pure (R) or (S)-enantiomers of 4-amino-3,3-dimethyl-piperidine compounds.</p> |
申请人 |
WOCKHARDT RESEARCH CENTRE;DESHPANDE, PRASAD, KESHAV;BHAVSAR, SATISH, BALIRAM;JOSHI, SANJEEV, NARHARI;KALE, RAJESH, PRABHAKAR |
发明人 |
DESHPANDE, PRASAD, KESHAV;BHAVSAR, SATISH, BALIRAM;JOSHI, SANJEEV, NARHARI;KALE, RAJESH, PRABHAKAR |