| 摘要 |
The title compds. (I; R3 = H, lower alkyl, aryl, heteroaralkyl; R4 = H, lower alkyl; Het = atoms required to complete a 5-6 membered ring; Z = S, O, CH2; m = 0-2; n = 2-3; m+n = 3-4), useful as histaminic H2 receptor antagonists, were prepd. by the reaction of II(X = QSO-, QSO2-, HS(CH2)nNH; Q = lower alkyl, aryl, aralkyl) and Het-(CH2)mY(Y = -Z(CH2)nNH2). Thus, 1.22 g 2-(3-chloro-2-pyridylmethylthio)etylamine dihydrobromide and 0.5 g nitropyrrole were reacted and refluxed for 10 days to give 2-[2-(3-choloro-2-pyridylmethylthio)ethylamino -3-nitropyrrole(m.p. 144-147≦̸C).
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