APTAMERS ON BASIS OF DNA FOR HUMAN CATHEPSINE G

摘要

FIELD: medicine. ^ SUBSTANCE: invention concerns identification of non-peptide inhibitors of cathepsine G. The given substances immediately inhibit biological functions of the target protein. The cathepsine G-inhibiting aptamers consist of linear DNA-sequences or polynucleotide sequences which have length of a chain at least of 60 nucleotides and not subjected to effective pairing of the bases. ^ EFFECT: offered aptamers are characterised by high selectivity and can be used at treatment and preventive maintenance of inflammatory processes and procoagulant conditions. ^ 7 cl, 3 dwg, 1 tbl