| 摘要 |
<p>4-12389/CGC 892/+ Canada Alphacarbamoyl-pyrrolpropionitriles, process for their manufacture, pharmaceutical preparations containing these compounds and their therapeutic application. of the disclosure The invention concerns the manufacture of compounds of the formula (I) wherein P1 is 2- or 3-pyrrolyl substituted in 1-position by lower alkyl or Ph-lower alkyl and being unsubstituted in the remaining 3 positions, or substituted therein by lower alkyl and/or one carboxy or lower carbalkoxy; R is hydrogen or lower alkyl, and Ph is phenyl, unsubstituted or substituted by one to throe identical or different members selected from lower alkyl, lower alkoxy, lower alkylthio, hydroxy, halogeno, trifluoromethyl, nitro, amino or lower alkanoylamino; of these compounds in their enol form, a lower alkyl enol ether or a lower alkanoyl enol-ester, or a salt thereof derived from a base. The compounds exhibit antiinflammatory and antiarthritic activity. They are prepared by condensing compounds of the formula wherein X is lower alkoxy, lower alkanoyloxy or halogeno.</p> |
