发明名称 |
1-SUBSTITUTED-3-ARYLTHIO-4-HYDROXYPYRROLIDINES |
摘要 |
<p>Trans isomers of 1-substituted-3-arylthio-4-hydroxypyrrolidines and derivatives thereof having the formula: are disclosed wherein R1 is hydrogen, lower-alkyl,-C(O)NH-lower-alkyl and -C(O)-NH-phenyl; R2 is loweralkyl, cycloalkyl and phenylalkyl; Ar is phenyl and substituted phenyl and the pharmaceutically acceptable addition salts thereof. The compounds have antidepressant activity in animals.</p> |
申请公布号 |
CA1133912(A) |
申请公布日期 |
1982.10.19 |
申请号 |
CA19800343330 |
申请日期 |
1980.01.09 |
申请人 |
ROBINS (A. H.) COMPANY, INC. |
发明人 |
WALSH, DAVID A. |
分类号 |
A61K31/40;A61P25/00;A61P25/24;A61P25/26;C07D207/12;C07D207/20;C07D491/04;(IPC1-7):07D207/12 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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