| 摘要 |
A process for the preparation of penicillanic acid 1,1-dioxide derivatives of the formula:- …<CHEM>… wherein X is Cl, Br, I or OSO2R<1> where R<1> is C1-C6 alkyl or C6H4R<2> where R<2> is H, Cl, Br, I, NO2, C1-C3 alkyl or C1-C3 alkoxy, by reducing a compound of the formula …<CHEM>… wherein X is as defined for formula (I), n is zero, 1 or 2; Y and Z are each Cl, Br or I, or Y is H and Z is selected from Cl, Br, I, C IDENTICAL N- (isocyano) and SCN- (isothiocyanato), or… Y is SeC6H4R<2> is as defined for formula (I), and Z is Cl or Br; with a specified reducing agent, followed by oxidation of a compound (VI) in which n is 0 or 1. …<??>The compounds (I) are intermediates for the production of valuable antibiotics. Also included are certain novel intermediates particularly those of the formula :- …<CHEM>… wherein X is Cl, Br, I or OSO2R<1> where R<1> is C1-C6 alkyl or C6H4R<2> where R<2> is H, Cl, Br, I, NO2, C1-C3 alkyl or C1-C3 alkoxy; n is zero, 1 or 2; Y<1> is H and Z<1> is C IDENTICAL N- or SCN-, or Y<1> is SeC6H4R<2> and Z<1> is Cl or Br, and R<2> is H, Cl, Br, I, NO2, C1-C3 alkyl or C1-C3 alkoxy. |
