| 摘要 |
<p>Therapeutically active organic compound exhibiting at least one group comprising a structure -S'-S"-R, wherein the group -S"-R is defined by R being an organic group comprised in a physiologically acceptable compound H-S"-R obtainable by the splitting of the disulfide bridge -S'-S"- in said structure, in which compound H-S"-R the sulfur atom S" is bound to a carbon atom in a heterocyclic aromatic ring in R having a configuration being such that the compound H-S"-R, while maintaining physiological acceptability, is stabilized, by tautomerism or resonance involving the sulfur atom S" bound to R, so as to be mainly excluded from reaction involving thiol disulfide exchange; S' being bound to an aliphatic carbon atom; and said compound, in addition to the group or groups comprising the structure -S'-S"-R, consisting of a residue of a therapeutically active organic base compound of non-polypeptide structure bound to S'. The invention also relates to a method of modifying a therapeutically active organic compound of non-polypeptide structure by introducing a structure -S'-S"-R according to above; a method of treating diseases by administration of a compound according to the invention and also to a pharmaceutical composition containing at least one compound according to the invention.</p> |
