Novel penicillin and cephalosporin compounds, a process for preparing the same and antibacterial composition containing the novel compounds.

摘要

A compound represented by the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="31" wi="70" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R, is hydrogen or methoxy; R<Sub>2</Sub> is hydrogen or hydroxy; R is
<Chemistry id="chema02" num="0002"><Image id="ia02" he="27" wi="84" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R<Sub>3</Sub> and R<Sub>4</Sub> are hydroxy or acyloxy, Y is oxygen, sulfur or <Image id="ia03" he="4" wi="5" file="IMGA0003.TIF" imgContent="character" imgFormat="TIFF" inline="yes" />N-R<Sub>5</Sub> wherein R<Sub>5</Sub> is hydrogen or lower alkyl, and Z is sulfur or <Image id="ia04" he="4" wi="4" file="IMGA0004.TIF" imgContent="character" imgFormat="TIFF" inline="yes" />N-R<Sub>5</Sub> wherein R<Sub>5</Sub> has the same meanings as defined above; and X is
<Chemistry id="chema03" num="0003"><Image id="ia05" he="16" wi="50" file="IMGA0005.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R<Sub>6</Sub> is acyloxy or nitrogen-containing hetero- cyclicthio which may have substituent(s), a pharmaceutically acceptable salt thereof, and a carboxylic ester thereof, a process for preparing the same and antibacterial composition containing the novel compounds.

This compound has improved antibacterial activity against Kleb. pneumoniae and Pseid. aeruginosa.