| 摘要 |
<p>NEW MATERIAL:The phthalimide A compound of formula (X is H, F, amino or carboxyl; R1 and R2 are lower alkyl, 2-chloroethyl or 2-hydroxyethyl). EXAMPLE:N-[N'-Di(2-chloroethyl)aminoethoxy]-4-fluorophthalimide. USE:Antitumor agent having excellent effect compared with the other imide compounds. PROCESS:A compound of formula wherein R1=R2=methyl and X=H can be prepared e.g. by dissolving dimethylaminoethanol in anhydrous acetone, adding metallic sodium to the solution to convert dimethylaminoethanol to sodium salt, and reacting with N-brom-phthalimide dissolved in anhydrous acetone.</p> |
