4-THIAPROSTAGLANDIN COMPOUND AND ITS PREPARATION

摘要

NEW MATERIAL:The compound of formulaI(R<1> is H or 1-10C alkyl; R<2> is 1-10C alkyl or cycloalkyl; R<3> is H or methyl; R<4> and R<5> are H or protecting group) and its non-toxic salt. EXAMPLE:4-Thiaprostaglandin E10. USE:Blood platelet coagulation suppressing agent and vasodilating agent. It is useful, e.g. for the remedy and prevention of thrombosis or as a hypotensor, etc. PROCESS:The compound of formulaIis prepared by reacting an alpha-allyl ketone compound of formula II (R<4-1> and R<5-1> are protecting group) with a thiol compound of formula III at -30-+200 deg.C for 10min-30hr, and if necessary, eliminating the protecting group and/or hydrolyzing the product.