Novel process for the preparation of intermediates of hmg-coa reductase inhibitors

摘要

Provided is a process for the preparation of chiral pentanoic acid derivative intermediates of the general formula II, which are useful in the preparation of HMG-CoA reductase inhibitors such as rosuvastatin or pitavastatin. The initial step of the process involves the use of the enzyme Candida antarctica lipase B. Further provided are intermediate compounds and their preparation.