| 摘要 |
<p>NEW MATERIAL:A compound of formulaI[R is -CH2R3 (R3 is H, residue of nucleophilic compound where tetrazolylthio substituted with dilower-alkylamino- lower-alkyl is excluded); R2NH is amino group protected appropriately], its salt and ester. EXAMPLE:7-[2-( 2-Aminothiazol-4-yl )-2-methoxyiminoacetamide]-3-carbamoyloxymethyl-3-cephem-4-carboxylic sodium salt or its syn-isomer. USE:Antibacterial: it is effective against a wide range of gram-positive and -negative bacteria and further resists beta-lactamase. PREPARATION:For example, the reaction between a compound of formula II and another compound of formula III is followed by removal of protecting groups, when necessary, to give the compound of formulaI.</p> |
