发明名称 |
PROCESS FOR SELECTIVELY PRODUCING ISOSORBIDE-5-NITRATE |
摘要 |
<p>The present invention is related to a new process for selectively preparing isosorbide-5-nitrate (1.4-3.6-dianhydrosorbitol-5-nitrate) by subjecting isomannide (1.4-3.6-dianhydromannitol) in an organic solvent or an aqueous-organic reaction medium to reaction with the equivalent amount of an acid halogenide or the anhydride of a benzene or haphthalene sulfonic acid possibly substituted by lower alkyl, lower alkoxy and/or halogen, of a perfluorolower alkane-sulfonic acid, of a lower alkanesulfonic acid or of a perfluoro - lower - alkanoic acid or with the equivalent amount of an acid halogenide of a carbamic acid or of sulphurous acid; subjecting the resulting isomannide2-ester in the presence of a solvent and possibly with heating, to reaction with an alkali metal salt or an ammonium salt of a benzoic acid possibly substituted by lower alkyl, lower alkoxy and/or halogen or of a lower alkanoic acid; converting the hydroxy group in the 5-position of the resulting isosorbide2-ester into the nitric acid ester group in manners known per se by reaction with nitric acid; and subjecting the resulting isosorbide-2-ester-5-nitrate to selective hydrolysis and/or reesterification in an organic or aqueous-organic solvent with an alkali metal hydroxide in manners known per se.</p> |
申请公布号 |
CA1132993(A) |
申请公布日期 |
1982.10.05 |
申请号 |
CA19800344874 |
申请日期 |
1980.02.01 |
申请人 |
SANOL SCHWARZ-MONHEIM G.M.B.H. |
发明人 |
SANDROCK, KLAUS;CORDES, GUNTER |
分类号 |
C07D493/04;(IPC1-7):07D493/04 |
主分类号 |
C07D493/04 |
代理机构 |
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