1-Substituted hydroxyiminomethyl-pyridinium salts, with an activity against organophosphate poisonings

摘要

1-substituted hydroxyiminomethyl-pyridinium salts, a process for the production of said compounds, compositions with an activity against organophosphate poisonings, and a process for the preparation of such compositions. The invention provides 1-substituted hydroxyiminomethyl-pyridinium salts of the formula 4, wherein R1 is a substituted or unsubstituted (hetero) aryl group or a corresponding dihydro group, R2 is a hydrogen, an alkyl or aryl group, R3 is hydrogen or an alkyl group and Z- is an anion suited for pharmacological purposes, pharmacological composition containing said compounds and a process for the preparation of said compounds by reacting a pyridine carboxaldoxime with a (hetero) arylhalide. The compounds in question show a good activity against nerve gases and are suited for prophylaxis too.