发明名称 |
Process for the preparation of esters of leukotriene A |
摘要 |
Esters of leukotriene A are conveniently prepared by reacting 9-oxo-5,6-trans-epoxynon-7(E)-enoates with 11-triphenylphosphoranylidene undec-6(Z),9(Z)-diene. Esters of leukotriene-A are useful intermediates in the synthesis of naturally occurring leukotrienes, which have been shown to be potent broncho-constricting substances. Novel intermediates to the esters of leukotriene A, 9-oxo-5,6-transepoxynon-7(E)-enoates and 7-oxo-5,6-transepoxyheptanoates, are disclosed.
|
申请公布号 |
US4352757(A) |
申请公布日期 |
1982.10.05 |
申请号 |
US19810230915 |
申请日期 |
1981.02.02 |
申请人 |
SMITHKLINE BECKMAN CORPORATION |
发明人 |
GLEASON, JOHN G.;KINZIG, CHARLES M.;BRYAN, DEBORAH L. |
分类号 |
C07C17/16;C07C29/17;C07C29/32;C07C33/02;C07C33/04;C07D303/40;C07D303/42;C07F9/54;(IPC1-7):C07D303/42 |
主分类号 |
C07C17/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|