METHOD FOR CHLORINATING THE CARBOXYLIC GROUP OF (ALPHA)-AMINOACIDS

摘要

"IMPROVED METHOD FOR CHLORINATING THE CARBOXYLIC GROUP OF .alpha.-AMINOACIDS" of the disclosure A method for chlorinating the carboxylic group of .alpha.- aminoacids (e.g. hydroxyphenyl-glycine) is described wherein the aminoacid is suspended in an optionally solvateforming solvent, treated with an excess of gaseous HCl and then with a chlorinating agent having the general formula ¢SOaCl2.R1R2NCHO! (e-g. SO Cl2.(CH3)2NcHo). A typical compound thus obtained is the dioxane hemisolvate of D(-)2-(p-hydroxyphenyl)glycyl chloride hydrochloride.