| 摘要 |
<p>Process for the optical resolution of mixtures of d-and 1-2-(6-methoxy-2-naphthyl)-propionic acids, which comprises preparing a solution of a mixture of d- and 1-2-(6-methoxy-2-naphthyl)-propionic acids and an optically active organic base in a predetermined organic solvent, slowly cooling the obtained solution and seeding with crystals of a salt of d-2-(6-methoxy-2-naphthyl)-propionic acid with the optically active organic base containing an amount by weight of the employed organic solvent, varying between about 9.5% and 14% and treating the obtained product with mineral acids in suitable organic solvents to obtain the free d-2-(6-methoxy-2-naphthyl)-propionic acid. …<??>The cinchonidine salt of d-2-(6-methoxy-2-naphthyl)-propionic acid containing about 9.5% to about 14% by weight of an amide selected from formamide, monomethylformamide, dimethylformamide, monoehtylformamide, diethylformamide, monomethylacetamide and dimethylacetamide and the preparation thereof.</p> |
