| 摘要 |
NEW MATERIAL:A piperazine derivative shown by the formula (R is H, alkyl, allyl, aryl, aralkyl; X is CH2, O; Y is CN, N) or piperidine derivative and its acid addition salt. EXAMPLE:4-Benzyl-1-(1-isochromanyl)piperidine. USE:An antiallergic. Suppressing the liberation of a chemical transmitter substance from a mastocyte or a basophil. Effective for preventing and remedying bronchial asthma, allergic rhinitis, etc. PROCESS:A piperidine derivative or a piperazine derivative is reacted with a given isochroman derivative or a tetraline derivative, to give a compound shown by the formula. |
