UN PROCEDIMIENTO PARA LA PREPARACION DE DIPEPTIDO-2-AMINO-1,2-DIDESOXI-D-GLUCOSAS, INMUNOLOGICAMENTE ACTIVAS.

摘要

Immunologically active compounds of the formula: (I.) oglycan fragment of the cell wall, more specifically, a muramyl dipeptide, namely, N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP). The addition of synthetic MDP to an emulsion of Freund's incomplete adjuvant (90% mineral oil and 10% Arlacel A) containing an antigen increases the level of antibodies against the antigen (humoral response) and induces delayed hypersensitivity (cellular immunity).