| 摘要 |
<p>2-Aminopyrimidones which are histamine H2- antagonists having the structure in which Het is an optionally substituted 2- or 4- imidazolyl, 2-pyridyl, 2-thiazolyl, 3-isothiazolyl, 3-(1,2,5)-thiadiazolyl or a 2-(5-amino-1,3,4-thiadiazolyl) group, Y is sulphur or methylene, Z is hydrogen or lower alkyl, A is C1-C5 alkylene and Het1 is a pyridyl group substituted by hydroxy or N-oxo and optionally substituted by lower alkyl or lower alkoxy, are prepared by a process in which an amine Het-CH2-Y-(CH2)2NH2 is reacted with a compound of Structure in which Q is nitroamino, lower alkylthio, benzylthio, chlorine, bromine or other group which can be displaced with a primary amine, and Het is a pyridyl group substituted by hydroxy, a protected hydroxy group or N-oxo and optionally substituted by lower alkyl or lower alkoxy, and removal of any hydroxy protecting groups.</p> |
