发明名称 |
Method for improving intestinal absorption of cephalosporin derivatives. |
摘要 |
<p>A method for improving the intestinal absorption of a cephalosporin derivative by bonding an oligopeptide having the general formula (I):
<Chemistry id="chema01" num="0001"><Image id="ia01" he="16" wi="75" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein
<UnorderedLists id="ula01" listStyle="none"><ListItem>X is a hydrogen atom, C1-15 alkyl group, R<Sub>3</Sub>CO- group wherein R<Sub>3</Sub> is a hydrogen atom or straight or branched chain C<Sub>1-15</Sub> alkyl group or a protective group easily removable by acid hydrolysis, hydrogenolysis or enzyme existing in a living body;</ListItem><ListItem>R, and R<Sub>2</Sub> each independently is a side chain of an amino acid constituting the oligopeptide; and</ListItem><ListItem>n is integer of 1 to 3, to any side chain at the 3-, 4- or 7-position of a 7-aminocephalosporanic acid derivative having antibacterial activity.</ListItem></UnorderedLists></p> |
申请公布号 |
EP0060422(A2) |
申请公布日期 |
1982.09.22 |
申请号 |
EP19820101508 |
申请日期 |
1982.02.26 |
申请人 |
ASAHI KASEI KOGYO KABUSHIKI KAISHA |
发明人 |
NISHIKIDO, JOJI;KODAMA, EIJI;SHIBUKAWA, MITSURU |
分类号 |
A61K38/00;C07D501/20;C07K5/078;(IPC1-7):07D501/20;07C103/52;61K37/02 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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