Antiarrhythmic tetrahydronaphthalene derivatives

摘要

Compounds are provided having the structure <IMAGE> wherein R1 and R2 may be the same or different and are hydrogen, lower alkyl, lower alkenyl, or hydroxylower alkyl, or R1 and R2 together with the nitrogen atom to which they are attached also form a heterocyclic radical which may contain another heteroatom, namely nitrogen, oxygen or sulfur; R3 and R4 may be the same or different and are hydrogen or lower alkyl. These compounds are useful in the treatment of arrhythmia. In addition, novel intermediates are provided having the structure <IMAGE> wherein R is hydrogen, benzyl or <IMAGE> These intermediates are also useful in treating acute myocardial infarction.