| 摘要 |
Compounds of the formula (III) and pharmaceutically acceptable salts thereof: <IMAGE> (III) wherein: R1 is a C1-6 alkoxy or C1-6 alkylthio group; R2 and R3 are the same or different and are hydrogen, halogen, CF3, C1-7acyl, C1-7 acylamino or amino, aminocarbonyl or aminosulphonyl optionally substituted by one or two C1-6 alkyl groups, C1-6 alkylsulphonyl, C1-6 alkylsulphinyl, C1-6alkoxy, C1-6 alkylthio, hydroxy or nitro or R1 and R2 taken together are methylenedioxy or ethylenedioxy in which case R3 is any one of the groups given for R2 and R3 above; R4 is C1-7 alkyl or a group -(CH2)sR6 where s is 0 to 2 and R6 is a C3-8 cycloalkyl group, or a group -(CH2)tR7 where t is 1 or 2 and R7 is a phenyl group optionally substituted by one or two substituents selected from C1-6 alkyl, C1-4alkoxy, trifluoromethyl and halogen, or a thienyl group; and n, p and q are independently 0 to 2 having useful pharmocological activity, a process for their preparation and their use.
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