| 摘要 |
The invention relates to new 3,4-dihydro-5H-2,3-benzodiazepine derivatives of general formula (I) and pharmaceutically acceptable acid addition salts thereof, <IMAGE> (I) wherein R represents a phenyl group optionally carrying one or two substituents selected from the group consisting of halogen, hydroxy, C1-4 alkoxy and benzyloxy; a furyl or a thienyl group, R1 stands for a hydrogen atom or a C1-4 alkyl group, R2 and R3 each represent hydrogen atom, C1-4 alkoxy, C4-7 cycloalkoxy or benzyloxy group. The new compounds of the general formula (I) can be prepared by reducing a 5H-2,3-benzodiazepine derivative of the general formula (II) <IMAGE> (II) wherein R, R1, R2 and R3 have the above-defined meanings, with an inorganic or organic hydride and/or complex metal hydride. The new compounds of the general formula (I) possess significant central nervous effects and can advantageously be used in the therapy. |
