| 摘要 |
Novel compounds exhibiting antiviral activity are disclosed, such compounds are represented by the formula: <IMAGE> wherein m represents the integer 0, 1 or 2; R represents trihalomethyl, alkyl or phenyl; R1 represents hydrogen, bromo, chloro, fluoro, cyano, nitro, amino, alkyl, alkoxy or trifluoromethyl; R2 represents hydroxyl, bromo, chloro, fluoro, cyano, acetyl, benzoyl, substituted benzoyl, alkyl, alkoxy, substituted alkoxy, benzyl, substituted benzyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, or the radical -O(CH2)nR4 wherein n represents the integer 1, 2 or 3 and R4 represents cyano or dialkylamino; R3 represents hydrogen, hydroxyl, bromo, chloro, fluoro, cyano, acetyl, benzoyl, substituted benzoyl, alkyl, alkoxy, substituted alkoxy, benzyl, substituted benzyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, or the radical -O(CH2)nR4 wherein n represents the integer 1, 2 or 3; and R4 represents cyano or dialkylamino; or alternatively R2 and R3 taken together represent the radical -O-C(X)2-O- wherein X represents hydrogen, bromo, chloro or fluoro. Methods of using the above-noted compounds and structurally related compounds to employ their antiviral activity are also disclosed as well as pharmaceutically-acceptable compositions.
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