| 摘要 |
The invention relates to substituted alkylphenylsulphonylguanidines with a heterocyclic radical of the general formula I <IMAGE> and to processes for the preparation thereof. In the formula I, X is a furan, thiophene or pyrrole radical which can in each case also be substituted by a di-C1-C4-alkylamino-C1-C4-alkyl group, or X is a 4-imidazolyl or 5-methyl-4-imidazolyl radical, R1 is hydrogen or a C1-C4-alkyl group, R2 is a halogen atom, a nitro group, an amino group, a sulpho group (-SO3H), a cyano group, a carboxyl group, a C1-C4-alkoxycarbonyl group, a formyl group, the group -CSNH2, the group CONR5R6 or the group -SO2NR5R6, R3 is hydrogen, a C1-C4-alkyl group, a C1-C4-alkoxy group, a mercapto group, an amino group, a cyano group, a carboxyl group, a C1-C4-alkoxycarbonyl group, a halogen atom, the group -CSNH2, the group -CONR5R6 or the group -SO2NR5R6, where R5 and R6 are identical or different and are hydrogen or C1-C4-alkyl groups, and one of the radicals R5 or R6 can also be a di-C1-C4-alkylamino-C1-C4-alkyl group, a C3-C8-cycloalkyl group, a C1-C6-alkoxy group or a phenyl radical, where the latter can also be substituted by halogen atoms, nitro, C1-C4-alkyl or C1-C4-alkoxy groups, and R4 is hydrogen, halogen or an amino group. The compounds have pharmacodynamic activity. They inhibit, for example, gastric fluid secretion and have an antihistamine effect.
|
