发明名称 |
PROCEDEU PENTRU PREPARAREA N-(2'-FURANIDIL)-5-FLUORO-URACILULUI |
摘要 |
<p>The present invention relates to a new process for the preparation of N1-(2'-furanidyl)-5-fluoro-uracil, also called Ftorafur, which is a very important anti-cancer compound. Said process comprises reacting 2,3-dihydrofuran with water in the presence of a catalytic amount of an acidic catalyst at a pH below 2.5, removing excess of unreacted starting materials and reacting the mixture obtained with silylated-5-fluoro-uracil is in the presence of a Friedel Crafts type catalyst uracil in an inert organic solvent. The new process has many advantages in comparison with those used so far.</p> |
申请公布号 |
RO72832(A) |
申请公布日期 |
1982.09.09 |
申请号 |
RO19770091810 |
申请日期 |
1977.10.11 |
申请人 |
ABIC LTD,IL |
发明人 |
MICHAEL,URI,IL;SASSON,ZABAR,IL;SCHOENBERGER,EVA,IL |
分类号 |
C07D405/04;C07D307/20;(IPC1-7):07D239/54 |
主分类号 |
C07D405/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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