| 摘要 |
PURPOSE:The reaction between 2,3-dimethoxy-5-methylhydroquinone-(1,4) and prenyl alcohol is conducted in isopropyl ether in the presence of boron trifluorideetherate complex to produce title compound useful as an intermediate of coenzyme Q in high yield. CONSTITUTION:The reaction of 2,3-dimethoxy-5-methylhydroquinone-(1,4) of formula I (R is H, acyl) or its acyl derivative with prenyl alcohol of formula II (n is 0 or positive integral number), its isomer or its reactive derivative is effected in isopropyl ether in the presence of boron trifluorideetherate complex to produce 2,3- dimethoxy-5-methyl-6-prenylhydroquinone of formula III and its acyl derivative. This reaction proceeds in homogenous system and the reaction temperature is preferably 30-60 deg.C. EFFECT:The control of the reaction temperature is simple. Isopropyl ether is excellent not only as the reaction solvent but also as the extraction solvent. The recovery also is simple. |
