PROCEDEU PENTRU PREPARAREA UNOR PIRIDINCARBOXAMIDOSULFONILUREE

摘要

Certain novel benzenesulfonylurea compounds derived from a nitrogen-containing carboxylic acid have been prepared by reacting an appropriate sulfonamide with an organic isocyanate or a trisubstituted urea equivalent thereof. The sulfonylureas so obtained are useful in therapy as oral hypoglycemic agents. Typical members include those compounds derived from 2-methoxynicotinic acid, of which 1-cyclohexyl-3-4-{4-[2-5-bromo-2-methoxynicotinamido)ethyl]benzenesulf onyl}urea is a most preferred embodiment.