Isomerisation of beta-lactam compounds and novel products obtained thereby.

摘要

Compounds of the formula (I):
<Chemistry id="chema01" num="0001"><Image id="ia01" he="19" wi="74" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R is an ethyl group which may optionally be substituted and n is 0 or 1, or a physiologically acceptable salt thereof, can be produced by subjecting to isomerization a compound of the formula (II):
<Chemistry id="chema02" num="0002"><Image id="ia02" he="21" wi="69" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R and n have the same meaning as defined above, or a salt thereof, by using a quaternary ammonium halide and are useful as a bactericide or disinfectant, and also a synergistic effect with penicillin and/or cephalosporin antibiotic agents.

Among the compounds of the formula (I), compounds shown by the formula:
<Chemistry id="chema03" num="0003"><Image id="ia03" he="18" wi="70" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R<Sub>6</Sub> is H or -SO<Sub>3</Sub>H, as well as salts thereof, are novel.