| 摘要 |
Cephalosporin analogs(I; R1 = H, hydroxy, lower alkoxy, aryl oxy, aralkuloxy,acyloxy, sulfonyloxy, lower alkylthio,arylthio, aralkylthio, lower alkyl sulfinyl, arylsuifinyl, aralkylsulfinyl; R2 = R1, lower alkyl, halogen substituted lower alkyl, azido, nitryl; R3 = H , alkyl, aryl, aralkyl; X1 = azido), having antibacterial activity, were prepd, by substituting X1 group and C00R3 of compd.(II) to the amino and COOH resp. Thus, intermediate (±)cis-2-t-butyloxycarbonyl-7-azi-do-l-azabicyclo≮4,2,0≉-oct-2-en-8-one 55mg was dissolved in the trifluoro acetic acid 2 ml, aged 10 min, condensed under the reduced pressure, benzene was added and then condensed again to give compd.(I; X =N3 ; R1,R2,R3 = H) 51mg.
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