| 摘要 |
<p>PURPOSE:To obtain the titled compound useful as a synthetic intermediate for an antibiotic, in high yield without forming trans derivatives as a by-product, by reducing a 2-azetidinone derivative substituted by a substituent group having a double bond at the 4-position by the catalytic hydrogenation. CONSTITUTION:The double bond (-CH=CH-) of a compound expressed by formulaI[phtN is phthalimide; Y is O or group of formula II (R3 is lower alkyl); R1 is carboxyl group, etc.; R2 is lower alkyl or phenyl]is reduced by the catalytic hydrogenation in a solvent, e.g. methanol, acetone or ethyl acetate, in the presence of Raney nickel or palladium-carbon as a catalyst at 0-100 deg.C to give the aimed compound. The amount of the catalyst is 10-30%w/w based on the weight of the compound expressed by formulaI, and the concentration of the compound expressed by formulaIis 0.01M/l-1M/l.</p> |
