| 摘要 |
The imidazole derivatives of the general formula: <IMAGE> (I) [wherein m represents an integer of 4 to 9, R1 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, and one of R2 and R3 represents a hydrogen atom, and the other represents a halogen atom or a phenyl group, or R2 and R3 together represent -(CH2)n-(in which n represents an integer of 4 to 6) or represent =CH2] and non-toxic salts thereof, which have a specifically inhibitory effect on the biosynthesis of thromboxane A2 (abbreviated as TXA2 hereafter) and are, therefore, useful as treating agents for diseases caused by TXA2 such as inflammation, cerebral apoplexy, myocardial infarction, acute cardiac death, cardiostenosis and thrombus etc.
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