| 摘要 |
3 sec -Epioleandomycin-Y 3 sec ,4 sec -carbonate, 4 sec -epioleandomycin-Y 3 sec ,4 sec -carbonate, their pharmaceutically acceptable salts, and pharmaceutical compositions containing them are disclosed. The compounds are antibacterial agents. Also disclosed are certain intermediates therefor, being 2 min -O-acyl derivatives of 8-de(spirooxiranyl)-8-iodomethyl-8-hydroxy-3 sec ,4 sec -anhydro-3 sec -deoxyoleandomycin-Y, 3 sec ,4 sec -anhydro-3 sec -deoxyoleandomycin-Y, 3 sec -epioleandomycin-Y, 4 sec -epioleandomycin-Y, 3 sec -epioleandomycin-Y 3 sec ,4 sec -carbonate and 4 sec -epioleandomycin-Y 3 sec ,4 sec -carbonate wherein said acyl group has the formula RCO- where R is H, C1-C5 alkyl, phenyl or benzyl. |
