NOVEL PEPTIDE AND ITS PREPARATION

摘要

NEW MATERIAL:A peptide expressed by formulaI(R<1> is H, substituted or unsubstituted alkanoyl, etc.; R<2> is carboxy, etc.; R<3> is carboxy, carbamoyl, etc.; R<4> is carboxy, carbamoyl, etc.; R<5> is H or a protecting group of the amino group; however, at least one of R<3> and R<4> is always carbamoyl) and a salt thereof. EXAMPLE:Heptanoyl-gamma-D-Glu-(alpha-OH)-(L)-mesoDAP-(L)-D-AlaOH-(D)-NH2. USE:An antimicrobial agent and antiulcer agent useful for treating infectious diseases caused by Gram-negative bacteria, Gram-positive bacteria, molds, etc. and cancers of men and animals. PROCESS:A compound expressed by formula II (Ra<1> is substituted or unsubstituted alkanoyl, etc.; Ra<2> is protected carboxy) or a salt thereof is reacted with a compound expressed by formula IV (Ra<5> is a protecting group of the amino group) or a salt thereof to give the compound expressed by formulaI(R<1> is Ra<1>; R<2> is Ra<2>; R<5> is Ra<5>).