N-METYL-D-GLUKAMINSALT AV 3,4-DIHYDRO-5-METYL-6-(2-METYL-PROPYL)-4-OXOTIENO(2,3-D)PYRIMIDIN-2-KARBOXYLSYRA OCH FARMACEUTISK KOMPOSITION INNEHALLANDE DETTA SALT

摘要

Treatment of the antiallergic agent 3,4-dihydro-5-methyl-6-(2-methylpropyl)-4-oxothieno[2,3-d]pyrimidine-2 -carboxylic acid with N-methyl-D-glucamine gives a salt with improved solubility. Solutions of this salt have pH values in a range acceptable for topical formulations. Additionally, solutions of the subject salt exhibit good stability which can be demonstrated by retention of potency. The salt is comprised of a 1:1 molecular ratio of the glucamine base to the acid.