Dibenzoxazonine, dibenzoxazecine, dibenzoxaazacycloundecane derivatives and their corresponding thia- and aza derivatives, their preparation and pharmaceutical compositions.

摘要

The present invention relates to new dibenz-oxazonine, dibenz-oxazecine or dibenzo-oxaazacycloundecane derivatives and corresponding thia- and aza derivatives thereof, of the general formula I:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="33" wi="88" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>or a pharmaceutically acceptable acid addition salt or nitrogen oxide thereof, in which
<UnorderedLists id="ula01" listStyle="none"><ListItem>X represents oxgyen, sulphur or the group NR<Sub>s</Sub>,</ListItem><ListItem>R<Sub>5</Sub> is hydrogen or alkyl (1-4 C),</ListItem><ListItem>R<Sub>1</Sub>, R<Sub>2</Sub>, R<Sub>3</Sub>, R<Sub>4</Sub> each represent hydrogen, hydroxy, halogen, cyano, alkyl, alkoxy,aralkoxy, alkylthio, methylenedioxy, CF<Sub>3</Sub>, N0<Sub>2</Sub>, NH<Sub>2</Sub>, hydroxyalkyl or an acyloxy group,</ListItem><ListItem>R represents hydrogen, alkyl, alkenyl or aralkyl, hydroxyalkyl or acyloxyalkyl and</ListItem><ListItem>n represents the number 0, 1 or 2, having valuable C.N.S. properties.</ListItem></UnorderedLists>