ISOXAZOLE DERIVATIVE, PROCESSES FOR ITS PREPARATION, COMPOSITIONS CONTAINING IT, AND ITS USE FOR COMBATING RHEUMATISM

摘要

5-Methylisoxazole-4-carboxylic acid(4-trifluoromethyl)-anilide and a process for its preparation in which 4-trifluoro-methylaniline is reacted with a 5-methylisoxazole-4-carboxylic acid derivative or it is reacted with diketene or a reactive acetoacetic acid derivative, the resulting acetoacetic acid 4-trifluoromethylanilide is heated with an orthoformic acid ester and the resulting 2-alkoxymethylene-acetoacetic acid 4trifluoromethyl-anilide is reacted with hydroxyl amine. The compound has an antirheumatic, antiphlogistic, antipyretic and analgesic action, and can be used for the treatment of multiple sclerosis.