| 摘要 |
NEW MATERIAL:The following physiologically active subsance B-52653XO shown by the formula. Appearance: colorless needle-like crystal. Elementary analysis value: C6H10N2O5H2O, calculated value(%) C 37.50, H 6.29, N 14.58. Molecular weight: 192+ or -10. Optical rotation: [alpha]D=+51+ or -(C=0.5, H2O). Solubility: insoluble in methyl alcohol, ethyl acetate, etc., and soluble in water, acetic acid, etc. USE:Exhibiting antibacterial action on Gram-positive and Gram-negative bacteria, useful as a physiologically active substance having inhibitory actions on an enzyme capable of hydroxylating collagen and proline. Useful as an intermediate for a compound having the above-mentioned action. PROCESS:For example, a bacterium belonging to the genus Streptomyces, capable of producing a physiologically active sybstance B-52653X, is cultivated in a medium, the physiologically sctive cubstance B-52653X is prepared and accumulated in the culture, this substance is collected, to give a compound shown by the formula. |
