摘要 |
<p>Optically active cephalosporin analogs represented by the general formula (I) <CHEM> wherein R<1> represents a hydrogen or a lower alkyl group, R<2> represents a hydrogen or a halogen atom, R3 represents a hydrogen or protective group of carboxylic acid, and the hydrogens at the 6- and 7-positions have cis configuration, and the pharmaceutically acceptable salts thereof, are produced by optically selective deacylation of an optically inactive acylated analog. The compounds are useful as intermediates in the preparation of optically active acylated antimicrobial agents.</p> |