摘要 |
<p>Medicaments contg. a halo biphenyl carboxylic acid of formula (I) or its salts with mineral or organic bases are new, (where X is halogen). The bases which may be used to form salt of (I) are pyridoxine, N-methyl ethanolamine, and calcium, magnesium, and aluminium hydroxides. The acids (I) are known, e.g. Grieve and Hay, J.Chem.Soc. 1933, 968. (I; X is 2-Cl) and its calcium and pyridoxine salts, (I; X is 2-Br) and its methyl ethanolamine salt, (I; X is 2-F), and (I; X is 3-Cl) are specifically claimed. LD50 is 100-150 mg/kg i.v. and 1000 mg/kg p.o. (mouse). They are hypolipemic and hypocholesterolemic agents, useful in the treatment of atherosclerosis.</p> |