| 摘要 |
New and pharmacologically useful 3 beta -amino-2 beta -hydroxy steroids of the androstane, oestrane and pregnane series are disclosed having the formula I: <CHEM> and pharmaceutically acceptable non-toxic acid addition salts of these compounds, wherein: (a) R1 is H, alkyl of one to six carbons (preferably lower alkyl, such as methyl), or acyl of one to eighteen carbons; (b) R2 is H or acyl of one to eighteen carbons; (c) R3 is H or methyl, preferably methyl; (d) Y is selected from the group consisting of O, acetalized O, H( beta OR4), R5( beta OR4), H( beta COCH3) and H( beta CHOR4CH3); (e) R4 is H or acyl of one to eighteen carbons; nd (f) R5 is a saturated or unsaturated alkyl group of one to four carbons; as well as pharmaceutically acceptable compositions comprising a pharmaceutically effective amount of a compound of the above formula, and a pharmaceutically effective carrier. The novel compounds have anti-arrhythmic properties, have no or minimal and transient haemodynamic effects, have no local anaesthetic properties and do not cause CNS stimulation. The compounds also have prophylactic effect and decrease infarctsize. |
