| 摘要 |
A synthetic antigen composition consisting in a synthetic vaccine comprising a physiologically acceptable carrier on which is disposed a synthetic peptide residue containing a sequence of 6 amino acids corresponding to the sequence of such amino acids in a protein antigen or allergen where the greatest local average hydrophilicity of the antigen or allergen is found, said local hydrophilicity of said protein antigen or allergen determined by: A. assigning relative hydrophilicity values to the amino acids of the protein antigen or allergen in accordnce with the relative relationship of such amino acids, B. determining the repetitive local average of hydrophilicity values at a plurality of points along the amino acid chain, C. determining from such points of repetitive averges the points of greatest local average hydrophilicity, said vaccine when free of an amino acid sequence corresponding to the entire protein antigen or allergen evoking a protective immunological response by stimuation of antibody formation against an antigen or allergen when introduced into a host animal. |
