发明名称 |
D-FENYLALANYL-L-PROPYL-L-ARGININALDEHYD-SULFAT OCH FOERFARANDEFOER DESS FRAMSTAELLNING |
摘要 |
The invention relates to D-phenylalanyl-L-prolyl-L-arginine aldehyde sulfate, highly stable in aqueous solution, and to a process for preparing it from D-phenylalanyl-L-prolyl-L-arginine aldehyde hemisulfate or NG-carboxy derivative containing an acid-sensitive protecting group at its amino terminal, wherein the acid sensitive amino terminal protecting group or optionally the NG-carboxy group is removed with 1 to 12 N sulfuric acid, applied in 1 to 12 equivalent amounts and the resulting free tripeptide aldehyde sulfate is isolated. The D-phenylalanyl-L-prolyl-L-arginine aldehyde sulfate of the invention possesses valuable anticoagulant activity. |
申请公布号 |
FI820086(L) |
申请公布日期 |
1982.07.14 |
申请号 |
FI19820000086 |
申请日期 |
1982.01.12 |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR RT |
发明人 |
BAJUSZ SANDOR;SZELL (HASENOEHRL) ERZSEBET;BARABAS EVA;BAGDY DANIEL |
分类号 |
C07K5/08;A61K38/00;A61K38/06;A61P7/02;C07K1/06;C07K1/113;C07K5/06;C07K5/065;C07K5/087 |
主分类号 |
C07K5/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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