发明名称 |
CEPHALOSPORIN ANTIBIOTICS |
摘要 |
Cephalosporin antibiotics of the general formula (I) (wherein Ra and Rb, which may be the same or different, each represent a C1-4 alkyl group or Ra and Rb together with the carbon atom to which they are attached form a C3-7 cycloalkylidene group; and R4 represents hydrogen or a 3- or 4-carbamoyl group with the proviso that Ra and Rb do not each represent a methyl group when R4 represents hydrogen) exhibit broad spectrum antibiotic activity, the activity being unusually high against gram-negative organisms such as strains of Pseudomonas organisms. The invention also includes the non-toxic salts and non-toxic metabolically labile esters of compounds of formula (I). Also described are compositions containing the antibiotics of the invention and processes for the preparation of such antibiotics. |
申请公布号 |
CA1127633(A) |
申请公布日期 |
1982.07.13 |
申请号 |
CA19790328413 |
申请日期 |
1979.05.25 |
申请人 |
GLAXO GROUP LIMITED |
发明人 |
O'CALLAGHAN, CYNTHIA H.;LIVERMORE, DAVID G.H.;NEWALL, CHRISTOPHER E. |
分类号 |
C07D501/06;A61K31/545;A61K31/546;A61P31/04;C07D;C07D277/20;C07D501/04;C07D501/46;C07D501/56;C07D501/60 |
主分类号 |
C07D501/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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