摘要 |
There are described compounds of formula I, <CHEM> in which R is a group of formula II, <CHEM> R<1>, R<2> and R<3>, which may be the same or different each represent hydrogen, alkyl, alkenyl, alkenyloxy, halogen, alkoxy, alkanoyl or hydroxy, one or more of R<4>, R<5> and R<6> represents alkyl, alkanoyl, alkenyl, -COOH or -ACOOH where A represents Y, OY or SY and Y represents a -CH=CH-, methylene, ethylene or 1,3-propylene chain, and the remainder of R<4>, R<5> and R<6> represent hydrogen, X represents a hydrocarbon chain having from 2 to 7 carbon atoms optionally substituted by hydroxy, E represents -S-, -O-, or -CH2-, and G represents -S- or -O-, (with various exceptions) and pharmaceutically acceptable derivatives of those compounds containing an acidic function. Processes for making the compounds of formula I, and the formulation and use of the compounds of formula I as antagonists of the slow reacting substance of anaphylaxis are also described. |