PROCESS FOR PREPARING 5-ACYL-1-HYDROCARBYLPYRROLE-2-ACETIC ACID

摘要

5-Acyl-1-hydrocarbylpyrrole-2-acetic acids were prepd. by Grignard reaction of the 5-cyano-1-hydrocarbylpyrrole-2-acetic acids. Thus, N-methylpyrrole was treated with chloral and NaCN to give 58% 5-cyano-1-methylpyrrole-2-acetic acid, which underwent Grignard reaction with p-BrC6H4Me to give 98% 1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid.