6,7,8,9-Tetrahydro-3H-benz(e)indolamine derivatives, processes for their preparation and intermediates used therein, and pharmaceutical compositions containing the indolamine derivatives.

摘要

The invention concerns compounds of the formula <CHEM> in which R<1>, R<2> and R<3> each is hydrogen or lower alkyl having 1 to 5 carbon atoms, and one of R<4> and R<5> is hydrogen and the other is NR<6>R<7> wherein R<6> and R<7> each is hydrogen or lower alkyl having 1 to 5 carbon atoms, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the compounds and pharmaceutical compositions. The compounds exhibit dopamine-receptor stimulating activity in a mammal and are useful for treating hyperprolactinemia, glactorrhea, amenorrhea, impotence, Parkinsonism, diabetes, acromegaly, hypertension and other central nervous system disorders. Also disclosed are 6,7,8,9-tetrahydro-3H-benz[e]indolamine-1,2-dione derivatives; 1,2,3,4-tetrahydronaphthalenediamine derivatives and 1,2,3,4,5,8-hexahydro-6-methoxy-naphthaleneamine derivatives which are useful as intermediates.