Polymers, preparation and use.

摘要

Polymers containing 55 to 90% of units of the formula (A) :
<Chemistry id="chema01" num="0001"><Image id="ia01" he="22" wi="58" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R<Sup>1</Sup> is a hydrogen atom or an alkyl group of 1 to 3 carbon atoms; and 10 to 45% of units of the formula (B) and (C):
<Chemistry id="chema02" num="0002"><Image id="ia02" he="24" wi="54" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry><Chemistry id="chema03" num="0003"><Image id="ia03" he="27" wi="55" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R<Sup>2</Sup> is a hydrogen group of 5 to 19 carbon atoms, for example n-C<Sub>11</Sub>H<Sub>23</Sub>, R<Sup>3</Sup> is a hydrogen atom or an alkyl group of 1 to 3 carbon atoms, R<Sup>4</Sup> is a hydrocarbon group of 5 to 19 carbon atoms, for example n-C<Sub>11</Sub>H<Sub>23</Sub> and X<Sup>-</Sup> is an anion and which contain at least 10% of units of formula (C) and are free from polymeric species having a molecular weight of less than 10,000 are described. The polymers possess antimicrobial activity against common pathogens. Isotonic aqueous solutions containing 0.002 to <Sub>0</Sub>.<Sub>0</Sub>25% of the polymer are suitable for the sterilisation of contact lenses for example by immersion of the lens in the solution overnight. Hydrophilic ointments containing from 0.002 to 0.25% of the polymer are suitable for the treatment of bacterial infection of lesions of the skin such as burns and ulcers.