发明名称 DIURETIC COMPOSITIONS COMPRISING 2,4-DIAMINO-5-(4-AMINO-3,5-DIMETHOXYBENZYL)-PYRIMIDINE AND A DIURETIC WHICH CAUSES EXCRETION OF POTASSIUM AND THEIR PREPARATION
摘要 <p>A composition having diuretic activity which contains a potassium-flushing diuretic and a potassium-retaining compound, said potassium-retaining compound is a compound of the formula <IMAGE> I wherein R1 and R2 are C1-6-alkyl or C2-6-alkenyl, and R3 and R4, independently, are hydrogen, C1-6-alkyl, C2-6-alkenyl or C1-6-acyl, or R3 and R4 together with the nitrogen atom are an optionally unsaturated 5-, 6- or 7-membered heterocyclic group, or a physiologically compatible salt thereof, are described.</p>
申请公布号 EP0009657(B1) 申请公布日期 1982.06.23
申请号 EP19790103328 申请日期 1979.09.07
申请人 F. HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT 发明人 DAUM, ADAM, DR.;FERNEX, MICHEL, DR.;WICK, ALEXANDER EDUARD, DR.
分类号 C07D239/49;A61K31/505;A61K31/54;A61K31/55;A61P7/10;C07D403/10;(IPC1-7):61K31/54 主分类号 C07D239/49
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